KMID : 1007520140230030965
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Food Science and Biotechnology 2014 Volume.23 No. 3 p.965 ~ p.969
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Phenylpropanoids from Red Kohlrabi Sprouts Inhibits Nitric Oxide Production in RAW 264.7 Macrophage Cells
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Lee Jae-Woong
Lee Dae-Young Baek Dong-Ryeol Jeong Rak-Hoon Lee Dong-Sung Kim Youn-Chul Kim Geum-Soog Baek Nam-In Lee Youn-Hyung
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Abstract
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The sprouts of red kohlrabi (Brassica oleracea var. gongylodes) were extracted with methanol, and the concentrated extracts were successively partitioned with ethyl acetate, n-butyl alcohol (n-BuOH), and H2O. From the n-BuOH fraction, four phenylpropanoids were isolated through repeated silica gel and ODS column chromatographies. On the basis of physico-chemical and spectroscopic data including NMR, MS, and IR, the isolated compounds were identified as 3-(3,4,5-trimethoxyphenyl)- 2E-propenoic acid methyl ester (1), (E)-sinapic acid methyl ester (2), (E)-sinapoyl glucoside (3), and lawsoniaside B (4). Moreover, the compounds dose-dependently inhibited NO production in RAW 264.7 cells with IC50 values of 41.22 (1), 38.32 (3), and 22.65 (4) ¥ìM, respectively. With further studies, these compounds may be potentially useful in developing new anti-inflammatory agents.
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KEYWORD
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anti-inflammation, phenylpropanoid, red kohlrabi
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